TRIGGER WARNING: Depression, s**cide attempt, and mentions of alcoholism.

Chase Brody first appeared in the video "The Jacksepticeye Power Hour — Chase Brody" (originally titled "Teabag Edition | Bro Average") uploaded on April 11, 2017. This video acts as his first—and only—Bro Average vlog, and we see Chase attempting to make low-quality trick shots. The trick shots he attempts to make are: "The Teabag" (throwing a teabag into a mug), "The Easter Egg Hunt" (throwing Cadbury eggs into a box, and "The Roar of the Lyon" (shooting a box with a Nerf gun). Chase makes sure to celebrate whenever he makes a shot. When we see Chase attempting, and sometimes making, the trick shots, he puts on a happy demeanor and a smile, as he doesn't want to let anyone know of the troubles he's facing off-screen. But despite his effort to hide them, in between the trick shots the camera person eavesdrops on Chase. Because of this, we find out that Chase is having marital troubles possibly due to his work, and begs his wife Stacy not to take their kids, but she tells him that she wants a divorce. When Chase tries to talk to his kids and say that he loves them, they hang up and Chase begins to cry. Every time the video cuts back to the trick shots, Chase appears to get more and more agitated, although he tries not to let it show for the camera. At the end of this video he professes his love for Stacy and that he doesn't want her to leave. Then he attempts suicide. The attempt is unsuccessful, as he opens his eyes.

The next time we see, or rather, hear, from Chase is at the end of the video "THEY'RE HERE | Stories Untold — Chapter 3," uploaded on May 7, 2018. As Sean is sharing what he thinks about the game, whispering starts to become audible and Sean's voice becomes muffled as he says. "Oh...this is good." The screen then goes black, and this may imply that Sean went into a coma. We hear Chase's voice in the darkness calling out to the YouTuber: "Jack.... Jack! This is Chase! You need to wake up." The video ends with radio sounding out morse code, which delivers the message "WHERE AM I?"

The come storyline seems to come back in the video uploaded on May 11, 2018, "TIE — A Game About Depression," which is also the next time we see Chase Brody. The ego talks about how he can only see his kids on the weekends, and he mentions how his best friend is in a coma—this seems to reference what happened at the end of "THEY'RE HERE | Stories Untold — Chapter 3." Towards the end of the video we can see Chase stroking a photograph as he's crying and drinking whiskey. Then we see him set the picture down and places his hat over it before leaving. This is how the video ends.

On May 14, 2018, Chase appears towards the end of the video "Dark Silence." What we see takes place at night; Chase walks through the seemingly empty house with nothing but a flame from a cigarette lighter. He can hear his kids screaming, which further prompts him to try and find them. When he goes upstairs he sees a figure standing at the end of the hall, bathed in red light, with his back to Chase. Then the figure turns, and it's clear that it's meant to be Antisepticeye. He starts walking towards Chase as the father as he screams, "Where are they?! What do you want from me?!"

October 13, 2019: Chase gets the second video solely focused on him. The video is titled "CHASE." Whether this video continues to follow the Sean-in-a-coma storyline is unknown. The video does not include any dialogue, and thus all of the story shown relies on visual clues. To start, we see a vacate notice, indicating that Chase no longer has a house to call home, and we see him going to his car. The inside of the vehicle is a mess, which alludes to the idea that Chase is becoming an alcoholic. Anti appears in the backseat of the car in this portion—as Chase searches for the picture of his family in the glove compartment, Anti is visble in the back. There's an idea that Anti is really the cause of Chase's problems and his depression. When Chase finds the picture, he screams in frustration, then starts the car and drives until he arrives in a forest. He exits the car, finds a cairn, and sets the picture from his glove compartment against it. It's unknown whether this mean his family is dead, missing, or just cut off contact with him. He drinks whiskey for a while, then is teleported from the woods into a car park. He looks around, confused. It's unclear how or why this happened, but we know that the other egos are involved.

We also see Chase, only for a fleeting moment, in "Don't Make Eye Contact," as Marvin the Magnificent has a vision while looking in a crystal ball.

As of writing this section of the guide, there has been another sighting that's believed to be Chase. In the video, "I got cancelled on Twitter," Chase can be heard pleading with Satan to see his family. From 5:55—6:08 he says, "Look Satan, I've done what you want. Please just let my family go. I plugged the coffee twice already, I told them to look at the graph and to subscribe to the channel—what more do you want from me?" And from 20:23—20:38 he says, "Look, it's been three times now. Can you please just put them on the phone so I can hear their voices and know they're okay?"

Other small appearances of Chase include:

—the animated short, "JACKIEBOY MAN BACK IN JACKTION!"

—the video, "L A U G H" in which he shows up in a fan-made clip; it recreates Sean's "LAUGH!" clip, but the board says "CRY" instead

—the video, "This Isn't Funny!" Sean reacts to a "Super Smash Bros" edit of his egos; Chase appears in the edit with the caption "Wants to see the kids"